USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: P48507 USC-OGP 2-DE database:  P48507 P48507 General information about the entry View entry in simple text format Entry name GSH0_HUMAN Primary accession number P48507 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glutamate--cysteine ligase regulatory subunit; AltName: Full=GCS light chain; AltName: Full=Gamma-ECS regulatory subunit; AltName: Full=Gamma-glutamylcysteine synthetase regulatory subunit; AltName: Full=Glutamate--cysteine ligase modifier subunit;. Gene name Name=GCLM Synonyms=GLCLR Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0505: pI=5.64; Mw=27760 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0787: pI=5.65; Mw=29986 Cross-references UniProtKB/Swiss-Prot P48507; GSH0_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name GSH0_HUMAN Primary accession number P48507 Secondary accession number(s) A8K334 D3DT45 M5A959 Q6FHC1 Q9NPX9 Q9NU74 Sequence was last modified on  February 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 152) Name and origin of the protein Description RecName: Full=Glutamate--cysteine ligase regulatory subunit; AltName: Full=GCS light chain; AltName: Full=Gamma-ECS regulatory subunit; AltName: Full=Gamma-glutamylcysteine synthetase regulatory subunit; AltName: Full=Glutamate--cysteine ligase modifier subunit; Gene name Name=GCLM Synonyms=GLCLR Encoded on Name=GCLM; Synonyms=GLCLR Keywords Acetylation; Alternative splicing; Complete proteome; Glutathione biosynthesis; Polymorphism; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L35546; AAA65028.1; -; mRNA EMBL AB809606; BAN05309.1; -; mRNA EMBL CR541833; CAG46632.1; -; mRNA EMBL AY773965; AAV28733.1; -; Genomic_DNA EMBL AK290449; BAF83138.1; -; mRNA EMBL AL049796; CAI21813.1; -; Genomic_DNA EMBL AL117351; CAI21813.1; JOINED; Genomic_DNA EMBL AL117351; CAI22976.1; -; Genomic_DNA EMBL AL049796; CAI22976.1; JOINED; Genomic_DNA EMBL CH471097; EAW73060.1; -; Genomic_DNA EMBL CH471097; EAW73061.1; -; Genomic_DNA EMBL BC041809; AAH41809.1; -; mRNA CCDS CCDS746.1; -. [P48507-1]; . CCDS CCDS81352.1; -. [P48507-2]; . PIR JC2474; JC2474; . RefSeq NP_001295182.1; NM_001308253.1. [P48507-2]; . RefSeq NP_002052.1; NM_002061.3. [P48507-1]; . UniGene Hs.315562; -; . UniGene Hs.596052; -; . UniGene Hs.711318; -; . ProteinModelPortal P48507; -; . SMR P48507; -; . BioGrid 108992; 18; . IntAct P48507; 5; . STRING 9606.ENSP00000359258; -; . DrugBank DB00151; L-Cysteine; . DrugBank DB00142; L-Glutamic Acid; . iPTMnet P48507; -; . PhosphoSitePlus P48507; -; . BioMuta GCLM; -; . DMDM 1346188; -; . OGP P48507; -; . EPD P48507; -; . MaxQB P48507; -; . PaxDb P48507; -; . PeptideAtlas P48507; -; . PRIDE P48507; -; . DNASU 2730; -; . Ensembl ENST00000370238; ENSP00000359258; ENSG00000023909. [P48507-1]; . Ensembl ENST00000615724; ENSP00000484507; ENSG00000023909. [P48507-2]; . GeneID 2730; -; . KEGG hsa:2730; -; . UCSC uc001dqg.2; human. [P48507-1]; . CTD 2730; -; . DisGeNET 2730; -; . GeneCards GCLM; -; . HGNC HGNC:4312; GCLM; . HPA CAB009568; -; . HPA CAB040554; -; . HPA HPA023696; -; . MalaCards GCLM; -; . MIM 601176; gene+phenotype; . neXtProt NX_P48507; -; . OpenTargets ENSG00000023909; -; . PharmGKB PA28613; -; . eggNOG KOG3023; Eukaryota; . eggNOG COG0656; LUCA; . GeneTree ENSGT00510000047658; -; . HOGENOM HOG000007111; -; . HOVERGEN HBG005923; -; . InParanoid P48507; -; . KO K11205; -; . OMA EYLQPYW; -; . OrthoDB EOG091G0DYU; -; . PhylomeDB P48507; -; . TreeFam TF105986; -; . BioCyc MetaCyc:ENSG00000023909-MONOMER; -; . BRENDA 6.3.2.2; 2681; . Reactome R-HSA-1614635; Sulfur amino acid metabolism; . Reactome R-HSA-174403; Glutathione synthesis and recycling; . UniPathway UPA00142; UER00209; . ChiTaRS GCLM; human; . GeneWiki GCLM; -; . GenomeRNAi 2730; -; . PRO PR:P48507; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000023909; -; . CleanEx HS_GCLM; -; . Genevisible P48507; HS; . GO GO:0005829; C:cytosol; NAS:UniProtKB; . GO GO:0017109; C:glutamate-cysteine ligase complex; IBA:GO_Central; . GO GO:0030234; F:enzyme regulator activity; IBA:GO_Central; . GO GO:0004357; F:glutamate-cysteine ligase activity; IEA:Ensembl; . GO GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; IPI:UniProtKB; . GO GO:0007568; P:aging; IEA:Ensembl; . GO GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl; . GO GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl; . GO GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl; . GO GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl; . GO GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl; . GO GO:0097069; P:cellular response to thyroxine stimulus; IEA:Ensembl; . GO GO:0006534; P:cysteine metabolic process; IEA:Ensembl; . GO GO:0006536; P:glutamate metabolic process; IDA:UniProtKB; . GO GO:0006750; P:glutathione biosynthetic process; IDA:UniProtKB; . GO GO:0035733; P:hepatic stellate cell activation; IEA:Ensembl; . GO GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl; . GO GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl; . GO GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; IBA:GO_Central; . GO GO:0050880; P:regulation of blood vessel size; IMP:UniProtKB; . GO GO:0051900; P:regulation of mitochondrial depolarization; IEA:Ensembl; . GO GO:0014823; P:response to activity; IEA:Ensembl; . GO GO:0042493; P:response to drug; IDA:UniProtKB; . GO GO:0044752; P:response to human chorionic gonadotropin; IEA:Ensembl; . GO GO:0051409; P:response to nitrosative stress; IEA:Ensembl; . GO GO:0007584; P:response to nutrient; IEA:Ensembl; . GO GO:0006979; P:response to oxidative stress; IDA:UniProtKB; . GO GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome; . Gene3D 3.20.20.100; -; 1; . InterPro IPR032963; Gclm; . InterPro IPR023210; NADP_OxRdtase_dom; . PANTHER PTHR13295; PTHR13295; 1; . Pfam PF00248; Aldo_ket_red; 1; . SUPFAM SSF51430; SSF51430; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]